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Original Article

Equivalence of Cholesterol Levels at Hospital-based Health-Check Program with Population-based Studies: A Comparative Study

Volume 2, Jan 2013

Pooja Maheshwari MD, Madhawi Sharma MD, Krishna Kumar Sharma MSc, Neeraj Krishna Goyal MD, Madhu Nahar Roy MD, Bhawani S. Mishra BAMS, Rajeev Gupta MD, Jaipur, India.

Background: High cholesterol is an important coronary risk factor. Only limited population-based studies have reported prevalence of hypercholesterolemia in India. Hospital-based data on cholesterol levels are available but have not been used to determine population-wide prevalence.

Objective:To determine equivalence of hospital-based cholesterol levels with population-based levels for identification of hypercholesterolemia.
Methods: Successive individuals undergoing measurements of total cholesterol levels at a tertiary-care hospital-based preventive health checkup program (primary and secondary prevention) were recruited. We compared total cholesterol levels in this group with two population-based studies – Jaipur Heart Watch (JHW) conducted in Jaipur and India Heart Watch (IHW) in 11 cities in India. Age-specific and age-adjusted levels and prevalence of hypercholesterolemia in the three groups were compared. Descriptive statistics are reported.

Results: We evaluated 45,534 subjects from hospital-based health checkup program, 1941 in JHW and 6123 in IHW. Age-adjusted mean levels of cholesterol in the three studies, respectively, were in men 170.6±46, 188.5±38 and 178.4±39 mg/dL (p<0.001), and in women 186.4±43, 182.2±36 and 184.6±39 mg/dL (p=n.s.). In hospital-based studies the levels were significantly lower among men in age groups >40 years and women >50 years, while no difference was observed in younger age-groups. Age-adjusted prevalence (%) of hypercholesterolemia >200 mg/dL in the three groups, respectively, were in men 28.1, 28.9 and 25.1 and in women 27.8, 25.6 and 24.9 (p<0.05). Hypercholesterolemia >240 mg/dL was in men 7.5, 6.8 and 6.2 and in women 7.8, 6.1 and 5.4 (p<0.01).

Conclusions: Cholesterol levels and hypercholesterolemia prevalence in hospital-based subjects are significantly different from population-based studies, especially in older subjects. (J Clin Prev Cardiol 2013;2(1):1-7)

Volume 2, Number 1, Pages: 1-7

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